Trigun takes place in the distant future on a deserted planet. Vash the Stampede is a gunfighter with a legend so ruthless he has a $60,000,000,000 bounty on his head. Entire towns evacuate at the rumor of his arrival. But the real Vash the Stampede, the enigmatic and conflicted lead character in Trigun, is more heroic, even though he usually acts like a complete idiot.

In a quicksand surrounded town called Makka, rumors spread of a legendary robber named Gasback is after the town. To protect it, Mayor Kepler has hired bounty hunters. These hunters have been following Gasback from town to town in hopes of getting the bounty. Vash the Stampede is in town, along with Meryl and Milly, along with the female bounty hunter Ameria and Nicholas D. Wolfwood.

Somewhere in Tokyo, there is a room. In that room is a black sphere. Periodically, people who should otherwise have died are transferred to the room. There, the sphere gives them special suits and weapons, and sends them out on a mission to kill aliens here on Earth. While these missions take place, the rest of the world is largely oblivious to them. These missions are lethal – few participants survive them. The sphere calls the shots, and it’s not the slightest bit nice. Its name… Gantz.

Saitama is a hero who only became a hero for fun. After three years of “special” training, though, he’s become so strong that he’s practically invincible. In fact, he’s too strong—even his mightiest opponents are taken out with a single punch, and it turns out that being devastatingly powerful is actually kind of a bore. With his passion for being a hero lost along with his hair, yet still faced with new enemies every day, how much longer can he keep it going?

A movie studio is being torn down. TV interviewer Genya Tachibana has tracked down its most famous star, Chiyoko Fujiwara, who has been a recluse since she left acting some 30 years ago. Tachibana delivers a key to her, and it causes her to reflect on her career; as she’s telling the story, Tachibana and his long-suffering cameraman are drawn in.